Modelling Submicron and Micron Particle Deposition in a Human Nasal Cavity

نویسندگان

  • Kiao INTHAVONG
  • Kai ZHANG
  • Jiyuan TU
چکیده

The size of a particle determines the deposition efficiency, as well as its deposition site. In this paper, different modelling techniques are presented for submicron and micron particles in a human nasal cavity. In addition this paper highlights some deficiencies in the default models available in a commercially available CFD software.For submicron particles the default Fluent Brownian model and a User-Defined Brownian model were evaluated. It was found that the default Brownian model significantly underpredicted submicron particle deposition, while the User Defined Brownian model provided an improvement in the particle deposition. The default Fluent turbulent particle tracking is known to overpredict the deposition of low inertial particles. This was evaluated against a damping function applied in the near wall region to reduce the normal fluctuating velocity. The application of the damping function improved the deposition efficiency for the low inertial particles.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Modelling the inhalation of drug particles in a human nasal cavity

A human nasal cavity was reconstructed from CT scans to make a Computational Fluid Dynamics (CFD) model. With this model, fluid flow and inhalation of aerosol analysis can be investigated. The surface of the interior nasal cavity is lined with highly vascularised mucosa which provides a means for direct drug delivery into the blood stream. Typical sprayed particles from a nasal spray device pro...

متن کامل

Assessing sinus aerosol deposition: benefits of SPECT-CT imaging.

PURPOSE Aerosol inhalation therapy is one of the methods to treat rhinosinusitis. However the topical drug delivery to the posterior nose and paranasal sinuses shows only limited efficiency. A precise sinusal targeting remains a main challenge for aerosol treatment of sinus disorders. This paper proposes a comparative study of the nasal deposition patterns of micron and submicron particles usin...

متن کامل

Study on Nasal Deposition of Micro Particles and Its Relationship to Airflow Structure

Moisturizing and keeping clean the air that moves through the nose and get into the lungs are the core responsibilities of the turbinates in human body and respiratory system. In certain situations, inflammatory reaction of tubinates is the first sign that they come across an allergenic substance which can lead to inflammation of them but in real life having such turbinates is not quite as harm...

متن کامل

CFD Study of the Air Flow Field and Particle Deposition in the Human Nasal Cavity

The nasal cavity is a main part of the human upper airway, and it has the important functions of respiration, heating and humidifying the inhaled air. The properties of the air flow in the nasal cavity may contribute to the occurrence of respiratory disease. In addition, particles are filtered by the nasal cavity. This function prevents toxic particles to enter into the human body, but it also ...

متن کامل

Local Deposition Sites of Drug Particles in a Human Nasal Cavity

INTRODUCTION ABSTRACT Particle depositional studies from nasal sprays are important for efficient drug delivery. The main influences on deposition involve the nasal cavity geometry and the nasal spray device of which its parameters are controlled by the product design. It is known that larger particle sizes (>>10μm) at a flow rate of 333 ml/s impact in the anterior portion of the nose, leaving ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2009